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The substantial difference in plasma steadiness results from the carbamate moiety which is an amide team in SB P17GA20 that is far more resistant to hydrolysisThe sulfur atom in the imidazobenzothiazole ring forms a weak hydrogen bond with the spine nitrogen of Cys 694The summary of the common characteristic pharmacophore speculation operate of Flt1 inhibitors is explained in Desk 3
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